ODCs

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1 OMIM reference -
2 associated genes
11 signs/symptoms

COMMON GENES: 1
PROTEIN INTERACTIONS: 1
COMMON SIGNS: 8

3 OMIM references -
2 associated genes
13 signs/symptoms

Brachydactyly type C

Brachydactyly type A1

BMPR1B	(UniProt - OMIM)		GDF5	(UniProt - OMIM)
GDF5	(UniProt - OMIM)		IHH	(UniProt - OMIM)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	BMPR1B	(0.9)	GDF5

Citations in the biomedical literature:

Brachydactyly type C		Brachydactyly type A1
	Synonym(s): (no synonyms)		Synonym(s): - Brachydactyly, Farabee type

	Classification (Orphanet): - Rare bone disease - Rare developmental defect during embryogenesis - Rare genetic disease		Classification (Orphanet): - Rare bone disease - Rare developmental defect during embryogenesis - Rare genetic disease

	Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -		Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -

	Epidemiological data: Class of prevalence: unknown Average age onset: neonatal/infancy Average age of death: - Type of inheritance: autosomal dominant		Epidemiological data: Class of prevalence: unknown Average age onset: neonatal/infancy Average age of death: - Type of inheritance: autosomal dominant

	External references: 1 OMIM reference - 1 MeSH reference: C537093		External references: 3 OMIM references - 1 MeSH reference: C537088


COMMON SIGNS	- Autosomal dominant inheritance - Clinodactyly of fifth finger - Cone epiphyses / epiphysis - Metacarpal anomalies / Archibald's sign - Short foot / brachydactyly of toes - Short hand / brachydactyly - Short stature / dwarfism / nanism - Symphalangy of fingers

Brachydactyly type C		Brachydactyly type A1
	Very frequent - Ulnar deviation of fingers Frequent - Thin / hypoplastic / hyperconvex fingernails Occasional - Talipes-valgus		Very frequent - Short big toe - Thumb hypoplasia / aplasia / absence Occasional - Scoliosis - Talipes-varus / metatarsal varus - Ulnar / cubital anomaly / absence / agenesis / hypoplasia / abnormal ulnar / cubital ray